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antiplatelet aggregation

antiplatelet aggregation

Molecules Free Full-Text Antiplatelet Aggregation ...

Interestingly, thepossible acetonide artifact 1 displayed significant antiplatelet aggregation induced not onlyby AA and collagen but also by platelet activating factor (PAF). Using

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Antiplatelet aggregation triterpene saponins from the ...

Among the tested compounds 1, 3, 5 and 10 exhibited strong inhibition of platelet aggregation in vitro, with IC50 values of 11.4±2.2, 10.4±1.3, 13.2±2.4, and 15.1±3.4μM, respectively. Keywords: Antiplatelet aggregation; Aquifoliaceae; Ilex rotunda; Rotundinosides A–D; Triterpene saponin.

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Antiplatelet aggregation and antithrombotic benefits

Accordingly, monoterpenoids are suggested as the main anti-platelet aggregation constituents from hawthorn leaves. Particularly, compounds 10 and 24 inhibited ADP-induced platelet aggregation and delayed FeCl3-induced thrombus in zebrafish.

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Antiplatelet aggregation and antithrombotic benefits of ...

2019-1-9  Antiplatelet aggregation and antithrombotic benefits of terpenes and flavones from hawthorn leaf extract isolated using activity-guided method Pinyi Gao a,b, #, Shuangshuang Li a,#, Kechun Liud, Chen Sund, Shaojiang Song a and Lingzhi Li a,* a School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based

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Antiplatelet Aggregation Activity of Walnut Hull

2017-6-1  The percentage of antiplatelet aggregation was calculated as follows: (5) APA = (A T − A C / A T) × 100 In this equation, APA is the percentage of antiplatelet aggregation, A T is the absorbance at the end of reaction for the test sample (extract- and thrombin-treated cells), and A C is the absorbance at the end of reaction for control sample (thrombin-treated cells).

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Screening for the antiplatelet aggregation quality

2020-9-5  At present, antiplatelet aggregation drugs commonly used for clinical purposes tend to cause adverse reactions such as bleeding, which limit their wide application . Many natural components in traditional Chinese medicine (TCM) exert potential therapeutic effects on antithrombosis by acting on multiple targets; this phenomenon has gradually become a research hotspot [ 6 , 7 ].

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Anti-inflammatory, Antiplatelet Aggregation, and ...

2020-5-9  In this study, we identified the active components with antiplatelet aggregation and antiangiogenesis activities, which may be related to the hemorrhagic disorder caused by this fungus. Moreover, we proposed a biosynthetic pathway of the isolated polyketide secondary metabolites and investigated their structure–activity relationship (SAR).

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Cytotoxic and Antiplatelet Aggregation Principles of

2013-9-25  Their antiplatelet aggregation and cytotoxic activities were examined to find potent antiplatelet aggregation and cytotoxic compounds from natural resources. Among them, dictamine ( 5 ), skimmianine ( 7 ), psoralen ( 8 ), chalepensin ( 12 ), clausindin ( 13 ), and graveolinine ( 16 ) showed significant inhibition of platelet aggregation, induced by arachidonic acid and collagen.

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List of Platelet aggregation inhibitors - Drugs

35 行  What are Platelet aggregation inhibitors? Platelet aggregation inhibitors work in different places

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Molecules Free Full-Text Antiplatelet Aggregation ...

Interestingly, thepossible acetonide artifact 1 displayed significant antiplatelet aggregation induced not onlyby AA and collagen but also by platelet activating factor (PAF). Using a bioactivity-guided fractionation method, two coumarins: minumicrolineacetonide (1)

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Antiplatelet aggregation activity of diterpene alkaloids ...

2002-8-2  Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica. Li L(1), Shen YM, Yang XS, Zuo GY, Shen ZQ, Chen ZH, Hao XJ. Author information: (1)Kunning Instiute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming, Yunnan 650204, PR China.

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Antiplatelet aggregation constituents from Annona

Antiplatelet aggregation constituents from Annona purpurea. Chang FR(1), Wei JL, Teng CM, Wu YC. Author information: (1)Graduate Institute of Natural Products, Kaohsiung Medical College, Kaohsiung, Taiwan, Republic of China, and Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China.

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Antiplatelet aggregation and antithrombotic benefits of ...

2019-1-9  Antiplatelet aggregation and antithrombotic benefits of terpenes and flavones from hawthorn leaf extract isolated using activity-guided method Pinyi Gao a,b, #, Shuangshuang Li a,#, Kechun Liud, Chen Sund, Shaojiang Song a and Lingzhi Li a,* a School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based

Get Price

Antiplatelet Aggregation Activity of Walnut Hull

2017-6-1  In this equation, APA is the percentage of antiplatelet aggregation, A T is the absorbance at the end of reaction for the test sample (extract- and thrombin-treated cells), and A C is the absorbance at the end of reaction for control sample (thrombin-treated cells).

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In Vitro Antiplatelet Aggregation Activity of Centella ...

2017-7-5  antiplatelet aggregation activity. Keywords: antiplatelet aggregation, Centella asiatica, n-hexane purification INTRODUCTION Platelet aggregation has many benefits for organism such as on homeostasis, xenobiotic phagocytoses, interaction with virus, bacteria or antigen-antibody complexes. However, it also has dangerous effects.

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Molecules Free Full-Text Antiplatelet Aggregation

Antiplatelet Aggregation and Platelet Activating Factor (PAF) Receptor Antagonistic Activities of the Essential Oils of Five Goniothalamus Species . by Bushra Abdulkarim Moharam 1, Ibrahim Jantan. 1,*, Fasihuddin bin Ahmad 2 and Juriyati Jalil 1. 1.

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Antiplatelet aggregation and antithrombotic benefits of ...

2019-1-9  Antiplatelet aggregation and antithrombotic benefits of terpenes and flavones from hawthorn leaf extract isolated using the activity-guided Food Function ( IF 4.171) Pub Date : 2019-01-09 00:00 Pinyi Gao,Shuangshuang Li,Kechun Liu,Chen Sun,Shaojiang Song,Lingzhi Li

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Comparison on Anticoagulation and Antiplatelet

2017-10-25  Comparison on Anticoagulation and Antiplatelet Aggregation Effects of Puerarin with Heparin Sodium and Tirofiban Hydrochloride: An In Vitro Study. Si-wei Li 1,2, Xue Feng 3, Hao Xu 1 Ke-ji Chen 1 Chinese Journal of Integrative Medicine volume 24, pages 103–108 (2018)Cite this article

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What is the Difference Between Anticoagulant and

2019-7-12  What is an Antiplatelet Antiplatelet is the s econd type of antithrombotic drugs – the first being anticoagulants. O ther names for antiplatelet drugs include antiaggregant, platelet agglutination inhibitor or platelet aggregation inhibitor. The main characteristic feature which discriminates between anticoagulant and antiplatelet

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Molecules Free Full-Text Antiplatelet Aggregation ...

Interestingly, thepossible acetonide artifact 1 displayed significant antiplatelet aggregation induced not onlyby AA and collagen but also by platelet activating factor (PAF). Using a bioactivity-guided fractionation method, two coumarins: minumicrolineacetonide (1)

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Design, Synthesis, and In Vitro Antiplatelet

In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. The in vitro antiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound 7f had potent antiplatelet aggregation activity with its IC50 27.6#x2009;#x3BC;mol/L ...

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Molecules Free Full-Text Antiplatelet Aggregation

Nine essential oils, hydrodistilled from different parts of five Goniothalamus species (G. velutinus Airy-Shaw, G. woodii Merr., G. clemensii Ban, G. tapis Miq. and G. tapisoides Mat Salleh) were evaluated for their ability to inhibit platelet aggregation in human whole blood using an electrical impedance method and their inhibitory effects on platelet activating factor (PAF) receptor binding ...

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Synthesis and antiplatelet aggregation activity of ...

Objective: To synthesize new pyridazinone derivatives and study their antiplatelet aggregation activity.Methods: A series of compounds were synthesized by introducing different piperazine groups in side chain of 6-(4-chloro-acetamido-phenyl)-4,5-dihydro-3(2H)-pyridazinones.The chemical structures of all the target compounds were confirmed by 1H-NMR,IR and elemental analysis.Born's turbidimetry ...

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Antiplatelet aggregation and antithrombotic benefits of ...

2019-1-9  Antiplatelet aggregation and antithrombotic benefits of terpenes and flavones from hawthorn leaf extract isolated using the activity-guided Food Function ( IF 4.171) Pub Date : 2019-01-09 00:00 Pinyi Gao,Shuangshuang Li,Kechun Liu,Chen Sun,Shaojiang Song,Lingzhi Li

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Bioassay based screening for the antiplatelet aggregation ...

2019-1-9  Bioassay based screening for the antiplatelet aggregation quality markers of Polygonum multiflorum with UPLC and chemometrics Journal of Pharmaceutical and Biomedical Analysis ( IF 3.209) Pub Date : 2019-01-09, DOI: 10.1016/j.jpba.2019.01.005

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Antiplatelet drugs

2013-6-4  Drugs that inhibit platelet adhesion and/or aggregation are used for prophylactic and/or long term anticlotting treatment.As with thrombolytic and anticoagulant drugs, their major side effect is BLEEDING. Antiplatelet drugs are often used in

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Antiplatelet agents - AMBOSS

2021-6-10  Antiplatelet agents are drugs that inhibit enzymes or receptors required for platelet activation, platelet aggregation, and/or thrombus formation. The most commonly used antiplatelet agent is acetylsalicylic acid ( aspirin ), which is an irreversible cyclooxygenase inhibitor with dose-dependent antiplatelet, antipyretic , analgesic , and ...

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List of Antiplatelet agents - Generics Only - Drugs

Antiplatelet agents are medicines that reduce the ability of platelets to stick together (called platelet aggregation) and inhibit the formation of blood clots. Antiplatelet agents play a major role in the treatment and prevention of myocardial infarction (heart attacks), stent thrombosis, and ischemic stroke (strokes caused by a blood clot).

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What is the Difference Between Anticoagulant and

2019-7-12  What is an Antiplatelet Antiplatelet is the s econd type of antithrombotic drugs – the first being anticoagulants. O ther names for antiplatelet drugs include antiaggregant, platelet agglutination inhibitor or platelet aggregation inhibitor. The main characteristic feature which discriminates between anticoagulant and antiplatelet

Get Price

Molecules Free Full-Text Antiplatelet Aggregation

Nine essential oils, hydrodistilled from different parts of five Goniothalamus species (G. velutinus Airy-Shaw, G. woodii Merr., G. clemensii Ban, G. tapis Miq. and G. tapisoides Mat Salleh) were evaluated for their ability to inhibit platelet aggregation in human whole blood using an electrical impedance method and their inhibitory effects on platelet activating factor (PAF) receptor binding ...

Get Price

Antiplatelet Agents Concise Medical Knowledge

Antiplatelet agents are medications that inhibit platelet aggregation, a critical step in the formation of the initial platelet plug. Abnormal, or inappropriate, platelet aggregation is a key step in the pathophysiology of arterial ischemic events. The primary categories of antiplatelet agents include aspirin, ADP inhibitors, phosphodiesterase ...

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Antiplatelet drugs

2013-6-4  Drugs that inhibit platelet adhesion and/or aggregation are used for prophylactic and/or long term anticlotting treatment.As with thrombolytic and anticoagulant drugs, their major side effect is BLEEDING. Antiplatelet drugs are often used in

Get Price

Antiplatelet agents - AMBOSS

2021-6-10  Antiplatelet agents are drugs that inhibit enzymes or receptors required for platelet activation, platelet aggregation, and/or thrombus formation. The most commonly used antiplatelet agent is acetylsalicylic acid ( aspirin ), which is an irreversible cyclooxygenase inhibitor with dose-dependent antiplatelet, antipyretic , analgesic , and ...

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Lancolides, Antiplatelet Aggregation Nortriterpenoids with ...

Lancolides, Antiplatelet Aggregation Nortriterpenoids with Tricyclo[6.3.0.0(2,11)]undecane-Bridged System from Schisandra lancifolia 论文题目英文: 作者:

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List of Antiplatelet agents - Generics Only - Drugs

Antiplatelet agents are medicines that reduce the ability of platelets to stick together (called platelet aggregation) and inhibit the formation of blood clots. Antiplatelet agents play a major role in the treatment and prevention of myocardial infarction (heart attacks), stent thrombosis, and ischemic stroke (strokes caused by a blood clot).

Get Price

Comparison on Anticoagulation and Antiplatelet Aggregation ...

Comparison on Anticoagulation and Antiplatelet Aggregation Effects of Puerarin with Heparin Sodium and Tirofiban Hydrochloride: An In Vitro Study LI Si-wei FENG Xue XU Hao CHEN Ke-ji 【摘要】:Objective: To detect the anticoagulation and antiplatelet ...

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What is the Difference Between Anticoagulant and

2019-7-12  What is an Antiplatelet Antiplatelet is the s econd type of antithrombotic drugs – the first being anticoagulants. O ther names for antiplatelet drugs include antiaggregant, platelet agglutination inhibitor or platelet aggregation inhibitor. The main characteristic feature which discriminates between anticoagulant and antiplatelet

Get Price

Antiplatelet Therapy in Ischemic Stroke and Transient ...

2019-1-10  Stroke is a leading cause of mortality and disability worldwide. 1 Initial manifestations of acute cerebral ischemia, such as ischemic stroke and transient ischemic attack (TIA), are often followed by recurrent vascular events, including recurrent stroke. 2 To reduce this burden, antiplatelet therapy is a key component of the management of noncardioembolic ischemic stroke and TIA. 3 This ...

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Platelet Aggregation Test: Purpose, Procedure, and Risks

2018-3-2  A platelet aggregation test requires a blood sample. The sample may be taken at a doctor’s office or a medical laboratory. To begin, the healthcare provider will put on gloves and clean the area ...

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